Vectorized instructive signals in cortical dendrites

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Implementations have had to develop their own strategies for dealing with this. Firefox initially used a linked-list approach that led to O(n) memory growth proportional to the consumption rate difference. In Cloudflare Workers, we opted to implement a shared buffer model where backpressure is signaled by the slowest consumer rather than the fastest.

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PFNA and PFOSA

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Rachel Ree

Nature, Published online: 25 February 2026; doi:10.1038/d41586-026-00293-6